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Alliance Experts

Wu Weidong
School of Public Health,Xinxiang Medical University



Papers in SCI

1.Wu W, R Muller, K Berhane, F Liu, S Fruin,, I Jasper, D Diaz-Sanchez, D Peden, R McConnell. (2013) Reactive oxygen species and inflammatory cytokine response of monocytes to ambient particles varies by proximity to a highway. Am J Respir Cell Mol Bio. (修改中).  

2.*Wu W, R Devlin, D Diaz-Sanchez, and JM Samet. (2013) Src-mediated EGFR activation regulates ozone-induced IL-8 expression. Environ Health Perspect (修改中).

3.Wu W,PB Bromberg and JM Samet. (2013) Zinc ions as effectors of environmental oxidative lung damage. Free Radic Biol Med, doi: 10.1016/j.freeradbiomed.2013.05.048. (特邀综述 IF 13)

4.McConnell R, W Wu, K Berhane, F Liu, F DiMeo, G Verma, D Diaz-Sanchez, and Scott Fruin. (2013) Variability in inflammatory cytokine response to respirable ambient particulate matter due to field collection procedures: Implications for chronic disease epidemiology. Am J Respir Cell Mol Bio. 48(4):497-502.

5.Feng F, Y Wu, S Zhang, Y Liu, L Qin, Y Wu, Z Yan, W Wu.  (2012) Macrophages facilitate coal tar pitch extract-induced tumorigenicity. PLoS One, 7(12):e51690. doi: 10.1371/journal.pone.0051690. Epub 2012 Dec 5.

6.*Wu W, DB Peden, R McConnell, S Fruin, and D Diaz-Sanchez. (2012) Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells. Particle and Fibre Toxicol. Aug 6; 9(1):31. [Epub ahead of print].

7.*Wu W, DB Peden, and D Diaz-Sanchez. (2012) Role of GSTM1 in resistance to lung inflammation. Free Radic Biol Med, 53(4):721-729. (特邀综述 IF 13)

8.Wang L, Liu X, Wu Y, Wu W, Wu Y. (2012) Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway. Oncol Rep. 28(4):1369-1375.

9.*Wu W, V Doreswamy, JM Samet, M Kesic, D Diaz-Sanchez, L Dailey, W Zhang, I Jaspers, and DB Peden. (2011) GSTM1 modulation of IL-8 production in human bronchial epithelial cells exposed to ozone. Free Radic Biol Med, 51(2):522-529.

10.*Wu W, JM Samet, DB Peden, and PA Bromberg. (2010) Phosphorylation of p65 is required for zinc oxide-induced IL-8 expression in human airway epithelial cells. Environ Health Perspect, 118(7):982-987.

11.Zhang G, Q Zhang, Q Zhang, L Yin, S Li, K Cheng, Y Zhang, H Xu, and W Wu. (2010) Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. J Cancer Res Clin Oncol, 136(4):587-594.

12.*Wu W, NE Alexis, PA Bromberg, I Jaspers, and DB Peden. (2009) Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells. Biochem Biophys Res Commun, 379(2):573-577.

13.Zhang H, N Li, Y Tang, W Wu, Q Zhang, and Z Yu. (2009)  Negative functional interaction of retinoic acid and TGF-beta signaling mediated by TG-interacting factor during chondrogenesis. Cell Physiol Biochem, 23(1-3):157-164.

14.Dai  P, SY Jeong, T Leng, Y Yu, W Wu, Y Du, L Xie, and X Chen. (2009) Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I interacting proteins. J Immunol, 182(6):3450-3460.

15.*Wu W, NE Alexis, X Chen, PA Bromberg, and DB Peden. (2008) Involvement of mitogen- activated protein kinases and NFB in LPS-induced CD40 expression on human monocytic cells. Toxicol Appl Pharmacol, 228(2):135–143.

16.Zhang Q, Wu W, Zhou F, Yao W, Yang H, Li Z, Zhao Y, Xu Y Li, S, Wu Y. (2008) Serum level of malondialdehyde, superoxide dismutases and cellular level of ras P21 and P53 in coke-oven workers. Life Sci  J, 5(1):38-42.

17.*Wu W, R Silbajoris, D Cao, PA Bromberg, Q Zhang, DB Peden, and JM Samet. (2008) Regulation of cyclooxygenase-2 expression by cAMP response element and mRNA stability in a human airway epithelial cell line exposed to zinc. Toxicol Appl Pharmacol, 231(2):260-266.

18.Wiser J, NE Alexis, Q Jiang, W Wu, C Robinette, R Roubey, DB Peden. (2008) In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radic Biol Med, 45(1):40-49.

19.Kim YM, D Cao, W Reed, W Wu, I Jaspers, T Tal, PA Bromberg, JM Samet.(2007) Zn2+-induced NFкB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation. Cell Signal, 19(3):538-546.

20.Ciencewicki JM, L Brighton, W Wu, M Madden, and I Jaspers. (2006) Diesel exhaust enhances virus- and poly(I:C)-induced toll-like receptor 3 expression and signaling in respiratory epithelial cells. Am J Physiol Lung Cell Mol Physiol,  290(6):L1154-1163.
21.Tal TL, LM Graves, R Silbajoris, PA Bromberg, W Wu, and JM Samet. (2006) Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+. Toxicol Appl Pharmacol, 214(1):16-23.

22.Kim, Y, W Reed, W Wu, PA Bromberg, LM Graves, and JM Samet. (2006) Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol,  290(5):L1028-1035.

23.*Wu, W, R Silbajoris, YE Whang, LM Graves, PA Bromberg, and JM Samet. (2005)  p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-inase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression. Am J Physiol Lung Cell Mol Physiol, 289(5):L883-889.

24.*Wu W, JM Samet, R Silbajoris, LA Dailey, D Sheppard, PA Bromberg, and LM Graves. (2004) Heparin-binding EGF cleavage mediates zinc-induced EGF receptor phosphorylation. Am J Respir Cell Mol Bio, 30(4):540-547.  

25.*Wu W, X Wang, W Zhang, W Reed, JM Samet, YE Whang, and AJ Ghio. (2003) Zinc induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. J Biol Chem, 278(30):28258-28263.

26.Samet JM, BJ Dewar, W Wu, and LM Graves. (2003) Mechanisms for Zn-induced signal initiation through the epidermal growth factor receptor. Toxicol Appl Pharmacol, 191(1):86-93.

27.Wu W, LM Graves, GN Gill, SJ Parsons, and JM Samet. (2002) Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for Zn-induced Ras activation. J Biol Chem, 277(27):24252-24257.

28.Wu W, I Jaspers, W Zhang, LM Graves, and JM Samet. (2002) Role of Ras in the epidermal growth factor receptor and NFκB signaling in human airway epithelial cells exposed to metals. Am J Physiol: Lung Cell Mol Physiol, 282: L1040-1048.

29.Huang YC, W Wu, AJ Ghio, JD Carter, R Silbajoris, RB Devlin, and JM Samet. (2002) Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash. Exp Lung Res, 28(1):19 38.

30.Wu W, JM Samet, AJ Ghio, and RB Devlin. (2001)  Activation of EGF receptor signaling in human bronchial epithelial cells exposed to Utah Valley particulate matter. Am J Physiol: Lung Cell Mol Physiol, 281:L483-489

31.Wu W, LM Graves, I Jaspers, RB Devlin, and JM Samet. (1999) Activation of EGF receptor signaling pathway in BEAS cells exposed to metals. Am J Physiol:Lung Cell Mol  Physiol, 277:L924-L931.

32.Samet JM, R Silbajoris, W Wu, and LM Graves.(1999) Tyrosine phosphatases as targets in  metal induced signaling in human airway epithelial cells. Am J Respir Cell Mol Biol, 21:357 364.

33.Samet JM, LM Graves, J Quay, LA Daily, RB Devlin, AJ Ghio, W Wu, PA Bromberg, and W Reed. (1998) Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am J Physiol:Lung Cell Mol Physiol, 275:L551-L558.

34.Wang QE, CH Han, W Wu, HB Wang, SJ Liu, and N Kohyama. (1999) Biological effects of man-made mineral fibers (I)--Reactive oxygen species production and calcium homeostasis in alveolar macrophages. Indus Health, 37(1), 62-67.

35.Wang QE, CH Han,YP Yang, HB Wang, W Wu, SJ Liu, and N Kohyama. (1999) Biological effects of man made mineral fibers (II)   their genetic damages examined by in vitro assay.  Indus Health, 37(3), 342 347.

36.Fan JG, QE Wang, SJ Liu, W Wu, G Jia, and LL Zhou. (1998) Pretreatment of chrysotile with rare earth compounds reduced its cytotoxicity by lessening surface charges. Biomed Environ Sci, 11:125-132.

Papers in Chinese core journals

37.梁宁,李冰, 宋金燕, 逯洋, 燕贞,王威,吴逸明,吴卫东*.(2012)纳米氧化锌致大鼠早期动脉粥样硬化改变的研究. 郑州大学学报(医学版), 47(3):626-628, 2012.

38.李冰,梁宁,贾陈志,燕贞,王威,吴逸明,吴卫东*.(2012)表皮生长因子受体在外源锌离子致大鼠急性肺部炎症中的表达及活化.郑州大学学报(医学版), 47(3):324-326, 2012.

39.贾陈志,关文池,李冰,梁宁,燕贞,王威,吴逸明,吴卫东*. (2011) 表皮生长因子受体抑制剂对外源锌离子致大鼠急性呼吸道炎症的影响. 郑州大学学报(医学版),46(3):349-351.

40.王威,李智涛,祝寒松,赵勇,王丽霞,燕贞,李时恩,许东,吴卫东, 吴拥军, 吴逸明. (2011) 煤焦沥青烟提取物致人支气管上皮细胞恶性转化细胞端粒损伤研究.中国职业医学, 38(5):369-372

41.张巧,程路明,邢瑞婷,马璐,李春阳,徐玉宝,吴卫东. (2011) NFkB在香烟烟雾凝集物诱导人支气管上皮细胞IL-8表达中的作用. 卫生研究,40(5):573-575.

42.张巧,谢惠玲,邢瑞婷,康雪敬,龚春梅,李春阳,吴卫东.(2011) 香烟烟雾凝集物对BEAS-2B细胞损伤作用及对IL-8表达的影响. 毒理学杂志, 25(3): 199-202.

43.燕贞,沈飞,李智涛,周舫,王娜,姚武,吴卫东,吴逸明.(2011)肺鳞癌组织中Annexin-1的表达及意义. 肿瘤防治研究, 38(1): 38-40.

44.燕贞,冯艳铭,周舫,李时恩,姚武,吴卫东,吴逸明. (2011)肺鳞癌组织中热休克蛋白27表达及意义. 中国公共卫生, 27(4):443-445.

45.关文池,张功员,李晟磊,赵国强,张巧,吴卫东. (2011) 沉默EC9706核干细胞因子基因对裸鼠移植瘤生长的作用. 中国肿瘤临床, 38(11):605-607.

46.张功员,关文池,李晟磊,张巧,吴卫东. (2011) 沉默EC9706细胞NS基因对裸鼠移植瘤组织中EGF、EGFR基因表达的影响. 第三军医大学学报,33(13):1370-1373.

47.李智涛,冯艳铭,王威,王丽霞,赵勇,祝寒松,吴卫东,吴逸明. (2011) 煤焦沥青烟提取物致人支气管上皮细胞BEAS-2B染色体不稳定性研究.工业卫生与职业病,37(3):129-136.

48.张巧 邢瑞婷 徐红辉 袁劲松 李春阳 吴卫东 吴逸明 程书钧.(2010) Rap2b基因真核表达载体构建及其对NIH3T3细胞P38通路的影响. 肿瘤防治研究,37(6):640-643.

49.燕贞,刘桂芝,王建设,周舫,姚武,吴卫东,吴逸明.(2010)蛋白质组学方法筛选早期肺鳞癌相关蛋白.肿瘤, 30(2): 130-133.

50.燕贞 张巧 徐磊 吴卫东* 任文杰 刘林洪 姚武 吴逸明.(2010) Toll样受体4在二氧化硅诱导巨噬细胞肿瘤坏死因子a合成中的作用.中华劳动卫生职业病杂志,28(6):427-429.


52.燕贞,李智涛,姚武,吴卫东,吴逸明.(2010) Ras相关核蛋白在肺鳞癌组织中的表达及意义.卫生研究, 39(5):583-585.

53.冯艳铭,燕贞,吴逸明,徐正顺,吴卫东. (2010) 亲环素A基因在非小细胞肺癌中的功能. 中华劳动卫生职业病杂志, 28(2):87-91.

54.张巧,段丽菊,徐红辉,袁劲松,吴卫东,吴逸明,高燕宁,程书钧.(2010) Rap2b基因表达对NIH3T3细胞集落形成及细胞伤口愈合能力的影响.卫生研究, 39(4):403-406.

55.徐磊,燕贞,吴卫东*,张功员,张巧,姚武,吴逸明. (2010) 纳米氧化锌对人呼吸道上皮细胞白细胞介素-8表达的影响. 郑州大学学报(医学版),1:39-42.


57.李智涛, 沈飞,燕贞,吴卫东,吴逸明.(2009) 染色质免疫沉淀技术分析肺腺癌A549细胞中p53蛋白与p21(上标 CIP1)和Bim基因转录启动子的结合. 生物技术通报,5:104-108.

58.张巧,徐磊,任文杰,刘林洪,耿明学,张功员,吴逸明,吴卫东. (2009) 二氧化硅对人呼吸道上皮细胞及巨噬细胞内IL-8和TNFa的诱导作用. 环境与职业医学, 26(4):337-339.

59.吴卫东*,张巧,姚武,吴逸明. (2008) 氧化锌对人呼吸道上皮细胞IL-8表达作用. 中国公共卫生,24(3):308-310.

60.沈飞,李智涛,吴逸明,吴卫东.(2008)激活蛋白-1与p53基因启动子结合的染色质免疫沉淀技术分析. 中华劳动卫生职业病杂志, 26(8):453-456.

61.张巧, 吴卫东*, 张同存, 时松和, 徐玉宝, 姚武, 吴逸明. (2008) 表皮生长因子受体及PI3K在硫酸锌诱导人呼吸道上皮细胞间粘附分子-1表达过程中的作用. 卫生研究, 37(5):552-557.

62.张巧, 杨海军, 吴卫东, 时松和, 徐玉宝, 姚武, 吴逸明. (2008) Zn2+对人Ⅱ型肺泡上皮A549细胞IL-8和TNF-α mRNA和蛋白表达水平的影响. 卫生研究,37(3):302-304.

63.张巧, 高丽霞, 杨海军, 朱敦彦, 时松和, 范清堂, 吴卫东, 吴逸明. (2008) 氧化锌对人II型肺泡上皮细胞IL-6、IL-8和TNF-α表达的影响. 毒理学杂志, 22(5):356-358.

64.高姗, 王琳, 吴卫东, 周舫, 吴逸明. (2008) 热化联合对肺癌A549细胞生长、c-Jun N-末端激酶磷酸化及热休克蛋白70表达的影响. 卫生研究,37(5):529-532.

65.冯艳铭, 王琳, 姚武, 吴卫东, 吴逸明. (2008)慢病毒介导的CyPA基因沉默对非小细胞肺癌细胞生长的影响. 山东医药,48(12):31-33.

66.王琳,高姗,张瑞芳,吴卫东,吴逸明 (2008). JNK通路及HSP70在热化疗抑制人小细胞肺癌细胞生长中的作用.第二军医大学学报, 29(2):142-145.

67.冯艳铭,吴卫东,燕贞, 姚武,吴逸明 (2008).亲环素在非小细胞肺癌中的高表达及其与临床病理特征的关系.第二军医大学学报, 29(2):146-149.

68.张功员, 尹  磊,   李晟磊,  吴卫东,  陈奎生,   张云汉,   张钦宪. (2008) 食管鳞状细胞癌组织中核干细胞因子、表皮生长因子和表皮生长因子受体mRNA的表达. 解剖学报,39(6):862-866.

69.高姗, 王琳, 吴卫东, 周舫, 吴逸明. (2008)不同温度热疗联合化疗对肺癌A549细胞生长及JNK磷酸化的影响. 郑州大学学报(医学版),43(3):459-462.

70.徐春燕, 高姗, 王琳, 吴卫东, 吴逸明.(2008) 不同温度热疗联合紫杉醇化疗对肺癌A549细胞增殖及Akt蛋白表达的影响. 郑州大学学报(医学版), 43(3):524-527.

71.张瑞芳,王琳,吴卫东,吴逸明.(2008)热疗与紫杉醇联合应用对NCI-H446细胞生长和MMP-2表达的影响.郑州大学学报(医学版), 43(5):901-904.

72.沈飞, 李智涛, 赵瑞红, 吴逸明, 吴卫东. (2008)ChIP技术分析A549细胞中AP-1与cyclinD1和caspase3基因转录启动子的结合. 第四军医大学学报,29(18):封2-01 .

73.张巧,陈景涛,吴卫东,袁劲松,程书钧,吴逸明. (2007) 肺癌组织中RAP2B的表达 癌变•畸变•突变, 19(6) :466-467.


75.栗建林,鲁凤明,吴卫东,刘霜,张丽帼,纪云晶. (2001)黑色氧化镍对细胞DNA损伤及基因表达的影响.中华劳动卫生职业病杂志,4:304-306.

76.栗建林,吴卫东,王起恩,张丽帼. (2000) 稀土对氧化镍致细胞DNA损伤及对氧自由基作用的影响. 中国稀土学报, 18(1):91-93.

77.梅瑜, 吴卫东, 刘世杰, 王起恩, 樊晶光. (1999) 染尘大鼠肺泡灌洗液对人胚肺细胞DNA含量的影响. 中国公共卫生, 15:22-23.

78.王起恩, 顾志刚, 韩春华, 柳德米拉•曲路, 吴卫东, 神山宣彦, 刘世杰.(1999)人造矿物纤维对细胞DNA损伤作用的体外研究.中华劳动卫生职业病杂志,17:14-16.


80.郭明洲,刘霜,王秀琴,易粹琼,侯晓华,吴卫东,王雪皎,张睿,鲁凤民,刘芝华. (1998) 林县食管癌组织和非癌食管组织差异DNA片段的克隆研究.中华预防医学杂志,3:168-170.    

81.鲁凤民, 刘霜, 吴卫东, 安文锋, 刘翔, 刘世杰. (1998)mRNA差异展示法检测氧化镍所致基因表达差异  北京医科大学学报, 30:26-28

82.王红兵, 王起恩, 吴卫东, 朱惠刚, 刘世杰.(1998)三种非遗传毒性致癌物对细胞周期及增殖细胞核抗原表达的影响.卫生毒理学杂志, 12:135-137

83.王起恩, 樊晶光, 吴卫东, 张侠, 赵修南, 刘世杰.(1998)吸烟与温石棉单独及联合作用对人胚肺细胞蛋白激酶C活性的影响.卫生毒理学杂志, 12:199-202.

84.梅瑜, 吴卫东, 李潭, 刘世杰.(1998)温石棉和石英引起肺组织细胞因子表达的比较研究.中华劳动卫生职业病杂志, 16:269-272.

85.王起恩, 韩春华, 吴卫东, 刘世杰, 神山宣彦.(1998)人造矿物纤维对肺泡巨噬细胞的毒作用研究.中华预防医学杂志, 32:327-329.

86.吴卫东, 鲁凤民, 刘霜, 刘翔, 栗建林, 刘世杰.(1997)黑色氧化镍诱发人胚肺细胞基因表达差异的研究.卫生毒理学杂志, 11:141-143.

87.王起恩, 樊晶光, 吴卫东, 刘世杰.(1997)温石棉与吸烟对肺泡巨噬细胞产生一氧化氮的影响.中华劳动卫生职业病杂志, 15:4-6.

88.樊晶光, 王起恩, 刘世杰, 贾光, 吴卫东.(1997)稀土化合物对温石棉溶血活性及表面特性的影响.中华劳动卫生职业病杂志, 15: 230-232.

89.樊晶光, 王起恩, 吴卫东, 刘世杰.(1997)几种化合物对石棉诱发肺泡巨噬细胞产生一氧化氮的抑制作用.中华预防医学杂志, 31: 31-33.

90.樊晶光, 王起恩, 贾光, 吴卫东, 刘世杰. (1996)几种化合物对温石棉溶血活性抑制作用的比较研究.工业卫生与职业病 ,22:193-195.

91.吴卫东, 刘世杰.(1995)温石棉对碱性色素的吸附作用.卫生毒理学杂志, 9:237-238.

92.吴卫东, 刘世杰, 尹宏.(1995)温石棉溶血机理.中国药理学与毒理学杂志,9:149-152.

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